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Which one of the following is not an environmental agent to decrease drug metabolizing ability?

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+1 vote
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in Drug Biotechnology by (138k points)
Which one of the following is not an environmental agent to decrease drug metabolizing ability?

(a) DDT

(b) Cigarette smoke

(c) Organophosphate insecticides

(d) Methacholine

I got this question in a job interview.

This interesting question is from Drugs Biotransformation in division Biotransformation of Drugs of Drug Biotechnology

1 Answer

+1 vote
by (1.1m points)
Correct choice is (d) Methacholine

The explanation: Methacholine inhibits the metabolism of acetylcholine by competing with it for cholinesterase. It is not an environmental factor. Halogenated pesticides e.g. DDT, polycyclic aromatic hydrocarbon e.g. cigarette smoke, organophosphate insecticides, heavy metals inhibit drug metabolizing of enzymes.

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