Question

Which of the following is the correct decreasing order of drug metabolism?

(a) Liver > lungs > kidneys > intestine > placenta > skin > adrenals

(b) Liver > lungs > kidneys > intestine > adrenals > placenta > skin

(c) Liver > kidneys > lungs > intestine > placenta > adrenals > skin

(d) Liver > lungs > intestine > kidneys > placenta > adrenals > skin

This question was posed to me in a national level competition.

Origin of the question is Drugs Biotransformation topic in section Biotransformation of Drugs of Drug Biotechnology

Answer 1

Right option is (a) Liver > lungs > kidneys > intestine > placenta > skin > adrenals

Best explanation: Liver is the primary site for metabolism. Of most of the drugs. It is because it has most of the enzymes in it that are in large numbers. Metabolism by other organs is very less because they have a very low quantity of enzymes present in them. Thus the order is liver > lungs > kidneys > intestine > placenta > skin > adrenals.