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P53 has a high turnover number.

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in Cytogenetics by (679k points)
P53 has a high turnover number.

(a) True

(b) False

The question was posed to me during an interview.

This intriguing question comes from Apoptosis and Cancer topic in division Cancer Biology & Methods in Cytogenetics of Cytogenetics

1 Answer

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Right option is (a) True

The explanation: In the normal cell p53 can interact with Mdm2 which acts as specific E3 ubiquitin ligase for p53 and ubiquitination leads to destruction of p53. It thus has a high turnover number and doesn’t accumulate in healthy cells.

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