Question

An E6 factor which binds to p53 and thus causes cancer is seem in case of _____________

(a) Epstein Barr Virus

(b) Human Papilloma Virus

(c) Melanoma

(d) Leukemia

This question was posed to me in class test.

The origin of the question is Apoptosis and Cancer in section Cancer Biology & Methods in Cytogenetics of Cytogenetics

Answer 1

Correct answer is (b) Human Papilloma Virus

For explanation I would say: HPV or Human Papilloma cells produce the E6 factor which binds p53. This in turn prevents the activation of apoptotic pathway triggered by DNA damage and leads to cell proliferation and cancer.