Question

Cell with DNA damage via a series of protein kinases  __________

(a) Activates CDC25

(b) Inactivated CDC25

(c) Activates WEE1

(d) Inactivates WEE1

This question was addressed to me in an interview for job.

This intriguing question comes from Cell Cycle Stages in chapter Cancer Biology & Methods in Cytogenetics of Cytogenetics

Answer 1

Correct option is (b) Inactivated CDC25

The explanation: CDC25 is a phosphatase that removes the inhibitory phosphate on the S Cycin-CDk complex that leads to the activation. WEE1 kinase adds this phosphate leading to inactivation. DNA damage requires sop of cell cycle thus CDC2 which helps in progression is inactivated.