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Sic1 can bind and inhibit ___________ Cdk and it is inhibited by ________ cdk.

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Sic1 can bind and inhibit ___________ Cdk and it is inhibited by ________ cdk.

(a) G1, M

(b) M, M

(c) S, S

(d) M, S

The question was posed to me during an online exam.

Enquiry is from Cell Cycle Stages topic in portion Cancer Biology & Methods in Cytogenetics of Cytogenetics

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Correct option is (b) M, M

Easiest explanation: M Cdk inactivated sic1 and Hct1 activity. It is however inhibited by the same. With decrease in M Cdk activity in the early G1 stage sic1 binds and inactivated it.

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