Question

Which one of the following is wrong about TAP?

(a) TAP can interact with the FG repeats

(b) TAP directly passes the mRNA through the

(c) siRNA against TAP will result in cytosolic accumulation of proteins with NLS

(d) TAP directly interacts with Aly/REF

I had been asked this question in examination.

My question is from Nuclear Export in section Nuclear Export & Post Mendelian Genetics of Cytogenetics

Answer 1

Correct answer is (c) siRNA against TAP will result in cytosolic accumulation of proteins with NLS

For explanation: TAP is the exportin that exports the mRNA out of the nucleus. It can bind to the poly A+ region of the mRNA and with help of Aly/REF protein it helps in export.