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The interaction of importin with Ran.GTP _____________________ its affinity for NLS.

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The interaction of importin with Ran.GTP _____________________ its affinity for NLS.

(a) Increases

(b) Decreases

(c) Remains same

(d) They never interact

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This interesting question is from Nuclear Export in section Nuclear Export & Post Mendelian Genetics of Cytogenetics

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Right answer is (b) Decreases

Explanation: In the nuclear side of the cytoplasm the interaction of the importing with the Ran.GTP complex decreases its affinity for NLS which releases the cargo.

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