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Which drugs gets mostly absorbed from the mouth?

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Which drugs gets mostly absorbed from the mouth?

(a) Acidic drugs and lipophilic drugs

(b) Lipophilic drugs and neutral drugs

(c) Neutral drugs and lipophilic drugs

(d) Lipophilic, neutral, basic drugs

This question was posed to me by my college director while I was bunking the class.

This interesting question is from Drugs Absorption from Non Oral Extravascular Sites topic in chapter Absorption of Drugs of Drug Biotechnology

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Correct option is (d) Lipophilic, neutral, basic drugs

Explanation: The pH of the mouth is 6.8. So no acidic drug can get absorbed through the lining of our mouth. Only lipophilic drugs, neutral drugs, and basic drugs get absorbed into the systemic circulation.

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