Question

Choose the wrong statement from the following.

(a) Maternal Igf2 is methylated to prevent expression

(b) Paternal H19 is methylated to avoid expression

(c) The enhancer can lead to expression of H19 in maternal gene

(d) The enhancer can’t lead to expression of Igf2 in paternal gene

I had been asked this question during an online interview.

The doubt is from Silencing and Genomic Imprinting in division Regulating Gene Expression in Eukaryotes of Cytogenetics

Answer 1

The correct answer is (a) Maternal Igf2 is methylated to prevent expression

To elaborate: It is true that the maternal Igf2 is not expressed in mice but the mechanism is via blockage of the enhancer by an insulator called CTCB binding to the CCCTC sequence in between the two adjacent genes. Rest of the options is correct.