Question

Which of the following is incorrect for Pader will syndrome?

(a) This is due to failure of inheritance of several non-imprint genes

(b) It is seen for chromosome 15

(c) It causes loss of active genes in 15q11-q13

(d) It occurs when the region containing specific genes in the maternal chromosome are missing

I had been asked this question in unit test.

The above asked question is from Silencing and Genomic Imprinting topic in chapter Regulating Gene Expression in Eukaryotes of Cytogenetics

Answer 1

Right choice is (d) It occurs when the region containing specific genes in the maternal chromosome are missing

For explanation: In case of Pader Willi syndrome the genes 15q11-q13 contained in the paternal chromosome are missing which leads to the defects. It is not due to the maternal factors missing.