Question

Why lipophilic drugs are absorbed easily?

(a) Less hydrolysed

(b) Favours passive diffusion

(c) Dissolution rate high

(d) Can easily merge with the cell membrane

I had been asked this question at a job interview.

This is a very interesting question from Prodrugs topic in division Prodrugs & Excretion of Drugs of Drug Biotechnology

Answer 1

The correct option is (b) Favours passive diffusion

To elaborate: Lipophilic drugs has high membrane-water partition coefficient thus it favours passive diffusion. These are more lipophilic, better absorbed and rapidly hydrolysed to the parent drug in blood.