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Which of the following is not a disadvantage of site-specific drug delivery?

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Which of the following is not a disadvantage of site-specific drug delivery?

(a) May lead to toxic effects on other non-target tissues

(b) May get diluted

(c) Less distribution time

(d) No penetrable to the target tissue

The question was asked in unit test.

My query is from Prodrugs in portion Prodrugs & Excretion of Drugs of Drug Biotechnology

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Right choice is (c) Less distribution time

To explain I would say: Less distribution time is an advantage for the drug. The disadvantages are may lead to toxic effects to other non-target tissues, may get diluted due to distribution and smaller fraction reach the target tissue, May not be able to penetrate the target tissue, higher distribution time.

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