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How are electrophiles generated?

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How are electrophiles generated?

(a) Through cytochrome P-450 system

(b) NADPH cytochrome P-450 reductase

(c) Different Flavin containing reductase

(d) Through cytochrome P-350 system

The question was posed to me in semester exam.

Enquiry is from Bioactivation and Tissue Toxicity in chapter Biotransformation of Drugs of Drug Biotechnology

1 Answer

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Right answer is (a) Through cytochrome P-450 system

Explanation: Electrophiles are species deficient in electron pair. The enzyme system through which they are generated is cytochrome-P450. Carbon, nitrogen, sulphur compounds can be metabolically activated to yield electrophiles.

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