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Which enzyme should be present for the conversion of angiotensinogen to angiotensin I?

(a) Renin

(b) Angiotensin converting enzyme

(c) Calcium ions

(d) Calcium anhydrase inhibitors

The question was posed to me in class test.

The origin of the question is Histamine, Bradykinin and Their Antagonists topic in division Histamine, Bradykinin and their Antagonists, Pharmacotherapy of Gastric Ulcer, Peptic Ulcer of Drug Biotechnology

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Correct choice is (a) Renin

To explain I would say: The juxtaglomerular cells of kidney release renin, this renin helps to convert angiotensinogen to angiotensin I. Angiotensin converting enzyme helps to convert angiotensin I to angiotensin II which gets attached to the angiotensin II receptor sites present in blood vessels and capillaries of lungs. Calcium channel blockers work in the vascular smooth muscle and decrease muscle contraction.

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