Question

Which enzyme of H. pyloric helps it to grow in the acidic medium of the stomach?

(a) Urease

(b) Amylase

(c) Protease

(d) Acid Hydrolases

I got this question in an interview for internship.

I'd like to ask this question from Pharmacotherapy of Peptic Ulcer in section Histamine, Bradykinin and their Antagonists, Pharmacotherapy of Gastric Ulcer, Peptic Ulcer of Drug Biotechnology

Answer 1

Correct option is (a) Urease

For explanation I would say: H. pylori primarily colonize in the antrum of the stomach it resides mainly within the gastric mucus. H. pylori have a high activity of the enzyme urease which enables it to colonize in the stomach. Infection can spread through fecal route. Infection thought to occur between parents and young children.