Question

Which will be the correct option for the marked place?

(a) Mucous cells

(b) Red blood cell

(c) Enterochromaffine like cells

(d) Antral G cell

This question was addressed to me during an online exam.

My question comes from Pharmacotherapy of Peptic Ulcer in chapter Histamine, Bradykinin and their Antagonists, Pharmacotherapy of Gastric Ulcer, Peptic Ulcer of Drug Biotechnology

Answer 1

Right option is (d) Antral G cell

The explanation is: Cholinergic neuron secretes acetylcholine that through circulation goes and bind to the muscarinic receptor in the parietal cell secrete acid into the gastric lumen. Enterochromaffine like cells secrete histamine which again go and bind to the H2 receptor and through the cAMP pathway helps the parietal cell to secrete acid. Gastrin secreted by Antral G cell is the hormonal control of acid secretion by parietal cell. Gastrin, Histamine and acetylcholine switch on the proton pump thus pumping H+ ions to produce acid in the gastric lumen.