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Which class of antibody is associated with an allergic reaction?

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Which class of antibody is associated with an allergic reaction?

(a) IgE

(b) IgA

(c) IgM

(d) IgG

I had been asked this question in unit test.

The query is from Drug Concentration and Pharmacologic Response topic in division Applications of Pharmacokinetic Principles, Diuretics, Drug Concentration and Pharmacologic Response of Drug Biotechnology

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Best answer
Right choice is (a) IgE

To explain I would say: Allergies are caused by a hypersensitivity reaction of the antibody class IgE which are located on mast cells in the tissues and basophils in the blood. When an allergen is encountered, it binds to IgE, which excessively activates the mast cells or basophils, leading them to release massive amounts of histamines. These histamines lead to inflammatory responses ranging from a runny nose to anaphylactic shock.

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