Question

Thiazide and thiazide-like diuretics pull water into the blood vessel from the surrounding tissues.

(a) True

(b) False

The question was asked in an interview for internship.

My question is based upon Diuretics topic in division Applications of Pharmacokinetic Principles, Diuretics, Drug Concentration and Pharmacologic Response of Drug Biotechnology

Answer 1

Correct choice is (b) False

To explain I would say: Osmotic diuretics such as mannitol pull water into the blood vessels and nephrons from the surrounding tissues, reduces cellular edema, increase urine production causing diuresis. That is why we can use osmotic diuretics during severe head injury. Pulling water from the surrounding blood vessels is not a function of thiazide like diuretics.