Question

Mannitol inhibits the enzyme carbonic anhydrase.

(a) True

(b) False

I had been asked this question during an online interview.

The origin of the question is Diuretics topic in section Applications of Pharmacokinetic Principles, Diuretics, Drug Concentration and Pharmacologic Response of Drug Biotechnology

Answer 1

Right option is (b) False

Easy explanation: Carbonic anhydrase inhibitors inhibit carbonic anhydrous, thus prevents the exchange of H+ ions with sodium and water. The enzyme carbonic anhydrase helps to make H+ ions available so they can be exchanged with sodium and water in the proximal tubules. Whereas osmotic diuretics such as mannitol pull water into the blood vessels and nephrons from the surrounding tissues, reduces cellular edema, increase urine production causing diuresis. The working of both the drugs are different but both of them helps in decreasing the fluid content.