Question

How to diagnose infection by H. pylori?

(a) Histology and culture

(b) Antibody test

(c) Urease CLO test

(d) Antibody test, Urease CLO test, Histology and culture

I got this question in an interview.

I need to ask this question from Pharmacotherapy of Peptic Ulcer in section Histamine, Bradykinin and their Antagonists, Pharmacotherapy of Gastric Ulcer, Peptic Ulcer of Drug Biotechnology

Answer 1

The correct choice is (d) Antibody test, Urease CLO test, Histology and culture

The best explanation: The majority of cases of peptic ulcer disease are related to H. pylori. The diagnosis of H. pylori infection must be confirmed prior to initiation of therapy. The methods can be histology and culture, antibody test, urease CLO test. H. pylori have a high activity of the enzyme urease which enables it to colonize in the stomach. Infection can spread through fecal route. Infection thought to occur between parents and young children.