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What do you understand by the term ‘manifestation’ related to diabetes?

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What do you understand by the term ‘manifestation’ related to diabetes?

(a) The immune system destroys beta cells and no more insulin is being produced

(b) The body becomes resistant to insulin

(c) Insulin is produced but not efficiently used up

(d) Beta cell destruction

This question was posed to me in semester exam.

My doubt is from Controlled Release Medication topic in division Controlled Release Medication of Drug Biotechnology

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The correct option is (d) Beta cell destruction

To explain I would say: Manifestation is the process of beta cell destruction which occurs very slowly. Hyperglycemia occurs when 80 – 90%  of the beta cells are destroyed. This then triggers stressor event (e. g. illness).

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