Question

What is the characteristic of matrix dissolution-controlled release systems?

(a) Release the drug along the entire length of GIT

(b) Prolonged their residence in the GIT and release

(c) Release only at a specific drug

(d) Employ waxes to control the rate of dissolution

I had been asked this question in an interview for internship.

My question is based upon Biopharmaceuticals topic in division Biopharmaceuticals of Drug Biotechnology

Answer 1

The correct option is (d) Employ waxes to control the rate of dissolution

Easy explanation: Matrix drugs are homogenous drugs since they are dispersed throughout the drug in a rate controlling medium. They employ wax such as beeswax, hydrogenated castor oil, etc. the drug is often first order from such matrixes. The wax embedded drug is prepared by dispersing the drug in molten wax and granulating it.