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Which of the following oral controlled release system is shown in the picture? (a)Matrix system

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Which of the following oral controlled release system is shown in the picture?

(a) Matrix system

(b) Encapsulated system

(c) Rigid matrix

(d) Swellable matrix

This question was addressed to me in an interview for internship.

The query is from Biopharmaceuticals topic in division Biopharmaceuticals of Drug Biotechnology

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Correct answer is (a) Matrix system

Explanation: They are very common and uses waxes such as bees wax, hydrogenated castor oil, etc. They control the drug dissolution rate by controlling the dissolution of the fluid penetration into the matrix. The drug release is often first order from such matrices. The wax embedded drug is prepared by dispersing the drug in molten wax and then granulating them.

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