Question

What are the characteristics of ion exchange resin drug complexes?

(a) Release the drug along the entire length of GIT

(b) Drug disperse in an insoluble matrix of rigid hydrophobic materials

(c) Hollow systems containing drug surrounded by a polymer membrane

(d) Formation of complexes between the drug and anion/cation exchange resins

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Question is taken from Biopharmaceuticals topic in division Biopharmaceuticals of Drug Biotechnology

Answer 1

The correct answer is (d) Formation of complexes between the drug and anion/cation exchange resins

Easiest explanation: Ionisable acidic and basic drugs are complexed with insoluble anion or cation exchange resins. The drug is released slowly by diffusion through the resin particle. Thus the controlled released of the drug is maintained. Drugs such as noscapine have been utilized by such methods.