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The absorption of the ophthalmic drug does not depend on which of the following?

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The absorption of the ophthalmic drug does not depend on which of the following?

(a) Physicochemical properties of the permeating molecule

(b) Drainage of tears

(c) Output of tears

(d) Size of the eyeball

The question was asked by my college director while I was bunking the class.

My question comes from Biopharmaceuticals topic in division Biopharmaceuticals of Drug Biotechnology

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Correct answer is (d) Size of the eyeball

The best I can explain: The absorption of the ophthalmic drug across the corneal membrane is a diffusion process and depends largely on the physicochemical properties of the permeating molecule that is the drug. It also depends upon the drainage and output of tears. Drugs of ophthalmic use are such as atropine, local anesthetics, epinephrine, etc.

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