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Which of the following oral controlled release system is shown in the picture? (a)Oral osmotic pump

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Which of the following oral controlled release system is shown in the picture?

(a) Oral osmotic pump

(b) Reservoir device

(c) Hydrodynamic pressure controlled system

(d) Altered density systems

The question was asked in an international level competition.

Question is taken from Biopharmaceuticals topic in division Biopharmaceuticals of Drug Biotechnology

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Right answer is (d) Altered density systems

The best I can explain: The picture shown is of high density pellets. This results in prolonged GI residence which will also be unaffected by food. Titanium dioxide, barium sulphate can be used to increase the density of the drug. The drug is coated on the heavy core and then covered by a diffusion controlled membrane.

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