Question

What are the characteristics of hydrodynamic pressure controlled systems?

(a) Buffering agents that adjust pH to the desired value

(b) Drug disperse in an insoluble matrix of rigid hydrophobic materials

(c) Generated by swelling hydrophilic hum

(d) Formation of complexes between the drug and anion/cation exchange resins

The question was posed to me in unit test.

My question is taken from Biopharmaceuticals in portion Biopharmaceuticals of Drug Biotechnology

Answer 1

Right answer is (c) Generated by swelling hydrophilic hum

For explanation: In hydrodynamic pressure controlled systems we use the hydrodynamic pressure generated by swelling a hydrophilic gum. The formulation comprises of rigid, shape-retaining house enclosing a collapsible, impermeable compartment containing the liquid drug. The systems are also called push-pull osmotic pumps.