Question

What is the characteristics of altered density systems?

(a) Release the drug along the entire length of GIT

(b) Prolonged their residence in the GIT and release

(c) Release only at a specific drug

(d) Use of high or low density pellets

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I would like to ask this question from Biopharmaceuticals topic in portion Biopharmaceuticals of Drug Biotechnology

Answer 1

Correct choice is (d) Use of high or low density pellets

Easiest explanation: The GI transit time is less than 24 hrs. Thus the density of the drugs changes such that the frequency of dosing can be reduced. The use of altered density approach use either high or low density pellets. These are hydrodynamically balanced systems. Titanium dioxide, barium sulphate can be used to increase the density.