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pH required for the production of penicillin will be ______________

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pH required for the production of penicillin will be ______________

(a) 8.0

(b) 7.5

(c) 6.5

(d) 5.0

This question was posed to me in a job interview.

Enquiry is from Production of Antibiotics (Isolation of Fermentation Products) in chapter Antibiotics & Enzyme Immobilization of Drug Biotechnology

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The correct option is (c) 6.5

Explanation: The pH should be has to be between 6.4 and 6.8 during the active production phase of penicillin. All the necessary precursors, ammonia, sugar, carbon dioxide, oxygen is controlled, by thorough monitoring of temperature and pH for optimal antibiotic production.

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