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How is streptomycin recovered?

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in Drug Biotechnology by (138k points)
How is streptomycin recovered?

(a) Paper chromatography

(b) Hydrophobic chromatography

(c) Size exclusion chromatography

(d) Ion exchange chromatography

The question was posed to me by my college director while I was bunking the class.

Origin of the question is Production of Antibiotics (Isolation of Fermentation Products) in portion Antibiotics & Enzyme Immobilization of Drug Biotechnology

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Right choice is (d) Ion exchange chromatography

The best explanation: Streptomycin is an antibiotic which is used to treat a number of bacterial infections. It is an extracellular product so they are removed by adsorption to ion exchange columns in chromatography. The period of operation is short and streptomycin sulfate is obtained in a single fraction with an overall yield of approximately 60 percent at a purity of 400 to 600 units per mg.

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