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Which of the following displaces Importin-alpha from the cargo transported inside the nucleus?

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Which of the following displaces Importin-alpha from the cargo transported inside the nucleus?

(a) Impotin-beta

(b) RanGTP

(c) CAS

(d) RanGTPase

This question was addressed to me by my school teacher while I was bunking the class.

The question is from Nucleus topic in portion Nucleus & Aerobic Respiration of Cell Biology

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Best answer
The correct option is (c) CAS

Best explanation: Once the complex composed of importin-alpha—importin-beta—molecule enters the nucleus, the importin-alpha and importin-beta has to be removed. RanGTP binds to Importin-beta and displaces it from the complex. Then the Cellular Apoptosis Susceptibility (CAS) protein which is an exportin and is bound to RanGTP, displaces Importin-alpha from the molecule with NLS sequence.

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