Question

Export of molecules from inside the nucleus to the cytoplasm needs hydrolysis  ________

(a) 1 GTP

(b) 1 ATP

(c) 2 GTPs

(d) 3 GTPs

I have been asked this question during a job interview.

My question is based upon Nucleus in section Nucleus & Aerobic Respiration of Cell Biology

Answer 1

The correct answer is (a) 1 GTP

To explain: The export of protein molecules from nucleus to cytoplasm is done due to the presence of Nuclear Export Sequence (NES). NES of the protein molecule can bind with an exportin and RanGTP to form a heterotrimeric complex. This complex is then transported outside nucleus by active transport as it requires the hydrolysis of one GTP molecule.