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Export of proteins with exportin CRM1 can be inhibited by ___________

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Export of proteins with exportin CRM1 can be inhibited by ___________

(a) Leptomycin A

(b) Leptomycin B

(c) Leptomycin D

(d) Leptomycin H

I got this question in final exam.

This is a very interesting question from Nucleus topic in division Nucleus & Aerobic Respiration of Cell Biology

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Right answer is (b) Leptomycin B

Explanation: CRM1 is an exportin which binds to the Nuclear Export Sequence (NES) of protein molecules destines to be transported out of the nucleus. The export process with exportin CRM1 can be stopped by Leptomycin B.

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