Question

Which of the following is not the function of Short Linear Motifs?

(a) Irreversible cleavage of the peptide at the SLiM

(b) Reversible cleavage of the peptide at the SLiM

(c) Moiety addition at targeted sites on SLiM

(d) Structural modifications of the peptide backbone

This question was posed to me in examination.

Question is from Protein Motifs and Domain Prediction topic in portion Sequence Alignment of Bioinformatics

Answer 1

The correct answer is (a) Irreversible cleavage of the peptide at the SLiM

For explanation: Short Linear Motifs are short stretches of protein sequence that mediate protein-protein interaction. SLiMs can act as recognition sites of endo-peptidases resulting in the irreversible cleavage of the peptide at the SLiM.