Question

Which of the following is false about the ‘loop’ structure in proteins?

(a) They connect helices and sheets

(b) They are more tolerant of mutations

(c) They are more flexible and can adopt multiple conformations

(d) They are never the components of active sites

I got this question in a job interview.

I want to ask this question from Protein Motifs and Domain Prediction in chapter Sequence Alignment of Bioinformatics

Answer 1

Correct choice is (d) They are never the components of active sites

Easiest explanation: Loops are frequently components of active sites as they are flexible in nature and as they are situated on the surface of the structure. Besides, they vary in length and 3-D configurations which give even more chances to be component of active sites.