Question

Which of the following statements about CATH-Gene3D and HAMAP databases is incorrect regarding its features?

(a) CATH-Gene3D describes protein families and domain architectures in complete genomes

(b) In CATH-Gene3D the functional annotation is provided to proteins from single resource

(c) HAMAP profiles are manually created by expert curators they identify proteins that are part of well-conserved bacterial, archaeal and plastid-encoded proteins families or subfamilies.

(d) HAMAP stands for High-quality Automated and Manual Annotation of microbial Proteomes

I have been asked this question during an online interview.

The origin of the question is Protein Family Databases topic in chapter Sequence Alignment of Bioinformatics

Answer 1

The incorrect statement regarding the CATH-Gene3D and HAMAP databases is:

(b) In CATH-Gene3D the functional annotation is provided to proteins from single resource

Explanation:

• CATH-Gene3D provides functional annotations derived from multiple sources, not just a single resource. It describes protein families and domain architectures across complete genomes, integrating information from various databases and annotations.
• The other statements are correct:
  • CATH-Gene3D indeed describes protein families and domain architectures in complete genomes.
  • HAMAP profiles are manually curated and identify proteins from well-conserved families in bacteria, archaea, and plastids.
  • HAMAP stands for High-quality Automated and Manual Annotation of microbial Proteomes, as the acronym suggests.