Question

Which of the following is a part of the statistical test of sequences?

(a) An optimal alignment between two chosen sequences is obtained at the end

(b) Unrelated sequences of the same length are then generated through a randomization process

(c) Unrelated sequences of the different length are then generated through a randomization process

(d) Related sequences of the same length are then generated through a randomization process

I have been asked this question by my school principal while I was bunking the class.

Question is taken from Statistical Significance of Sequence Alignment in division Pairwise Sequence Alignment of Bioinformatics

Answer 1

Correct option is (b) Unrelated sequences of the same length are then generated through a randomization process

To explain I would say: Unrelated sequences of the same length are then generated through a randomization process in which one of the two sequences is randomly shuffled. And the next step is that a new alignment score is computed for the shuffled sequence pair.