Question

Which of the following is untrue about SCOP and CATH?

(a) The definition for class in CATH is quite dissimilar to that in SCOP

(b) The definition for class in CATH is based on secondary structure content

(c) Architecture is a unique level in CATH, intermediate between fold and class

(d) The definition for class in CATH is similar to that in SCOP

I got this question in examination.

I want to ask this question from Protein Structure Classification topic in chapter Structural Bioinformatics of Bioinformatics

Answer 1

Correct option is (d) The definition for class in CATH is similar to that in SCOP

Easiest explanation: The topology level is equivalent to the fold level in SCOP, which describes overall orientation of secondary structures and takes into account the sequence connectivity between the secondary structure elements. The homologous superfamily and homologous family levels are equivalent to the superfamily and family levels in SCOP with similar evolutionary definitions, respectively.