Question

In dynamic programming, in ab initio methods, Often ________ base pairing and energy terms of the base pairing _____ incorporated into the scoring process.

(a) G-C, are

(b) G–U, are not

(c) G–U, are also

(d) G-C, are not

This question was posed to me during a job interview.

My query is from Ab Initio Approach in section RNA Structure Prediction of Bioinformatics

Answer 1

Right answer is (c) G–U, are also

The best explanation: Although the traditional structure comprises of A–U and G–C base pairs, G-U base pairing is incorporated into the scoring process. A path with the maximal score within a scoring matrix after taking into account the entire sequence information represents the most probable secondary structure form.