Question

Progenitor sequences represented by the ______ branches of the tree are derived by alignment of the _______ sequences.

(a) outer, outermost

(b) inner, outermost

(c) inner, innermost

(d) outer, innermost

I have been asked this question in an interview for job.

This intriguing question originated from Progressive Methods of Multiple Sequence Alignment in division Multiple Sequence Alignment of Bioinformatics

Answer 1

The correct answer is (b) inner, outermost

For explanation I would say: Progenitor sequences represented by the inner branches of the tree are derived by alignment of the outermost sequences. These inner branches will have uncertainties where positions in the outermost sequences are dissimilar.