Question

Jpred combines the analysis results from six prediction algorithms, including PHD, PREDATOR, DSC, NNSSP, Jnet, and ZPred.

(a) True

(b) False

The question was posed to me in my homework.

This interesting question is from Coiled Coil Prediction in portion Secondary Structure Prediction of Bioinformatics

Answer 1

Right choice is (a) True

To explain I would say: The query sequence is first used to search databases with PSI-BLAST for three iterations. Redundant sequence hits are removed. The resulting sequence homologs are used to build a multiple alignment from which a profile is extracted. The profile information is submitted to the six prediction programs. If there is sufficient agreement among the prediction programs, the majority of the prediction is taken as the structure.