Question

Leucine zipper domains are a special type of coiled coils found in transcription regulatory proteins which contain two anti parallel α-helices held together by hydrophobic interactions of leucine residues.

(a) True

(b) False

I got this question in homework.

My doubt is from Coiled Coil Prediction in division Secondary Structure Prediction of Bioinformatics

Answer 1

Right option is (a) True

To explain: The heptad repeat pattern is L-X(6)-L-X(6)-L–X(6)-L. This repeat pattern alone can sometimes allow the domain detection, albeit with high rates of false positives. The reason for the high false-positive rates is that the condition of the sequence region being a coiled coil conformation is not satisfied. To address this problem, algorithms have been developed that take into account both leucine repeats and coiled coil conformation to give accurate prediction.