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In Multicoil, The scoring matrix is constructed based on a database of known three-stranded coiled coils only.

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In Multicoil, The scoring matrix is constructed based on a database of known three-stranded coiled coils only.

(a) True

(b) False

The question was posed to me in class test.

The question is from Coiled Coil Prediction topic in division Secondary Structure Prediction of Bioinformatics

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The correct option is (b) False

The explanation: Multicoil is a web-based program for predicting coiled coils. The scoring matrix is constructed based on a database of known two-stranded and three-stranded coiled coils. The program is more conservative than Coils. It has been recently used in several genome-wide studies to screen for protein–protein interactions mediated by coiled coil domains.

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