Question

Which of the following is not true about iterative methods?

(a) Genetic Algorithm is method used for under this

(b) Hidden Markov Models are used for Multiple Sequence Alignment

(c) The objective is to improve the overall alignment score

(d) MultAlin recalculates global scores

I got this question in exam.

My doubt stems from Iterative Methods of Multiple Sequence Alignment topic in chapter Multiple Sequence Alignment of Bioinformatics

Answer 1

Correct answer is (d) MultAlin recalculates global scores

Easiest explanation: MultAlin (Corpet 1988) recalculates pair-wise scores during the production of a progressive Alignment. In addition, it uses these scores to recalculate the tree, which is then used to refine the alignment in an effort to improve the score.