Question

In addition to the canonical base pairing, there often exists non-canonical base pairing such as _________ and ________ base paring.

(a) G, U

(b) G, C

(c) U, C

(d) A, C

This question was addressed to me during an online interview.

This key question is from Types of RNA Structures topic in portion RNA Structure Prediction of Bioinformatics

Answer 1

Right answer is (a) G, U

For explanation I would say: There often exists non-canonical base pairing such as G and U base paring. The G–U base pair is less stable and normally occurs within a double-strand helix surrounded by Watson–Crick base pairs. Finally, the tertiary structure is the three-dimensional arrangement of bases of the RNA molecule.