Question

In 1971, first estimation of the energy associated with regions of secondary structure by extrapolation from studies with small molecules was done and then an attempt was made to predict which configurations of larger molecules were the most energetically stable.

(a) True

(b) False

This question was posed to me in examination.

My doubt is from Limitations of Prediction in section RNA Structure Prediction of Bioinformatics

Answer 1

Right answer is (a) True

The best explanation: Energy estimates included the stabilizing energy associated with stacking base pairs in a double-stranded region and the destabilizing influence of regions that were not paired. Pipas and McMahon (1975) developed computer programs that listed all possible helical regions in tRNA sequences.