Question

Profiles are found by performing the _____ MSA of a group of sequences and then removing the _______ regions in the alignment into a smaller MSA.

(a) local, more highly conserved

(b) global, low conserved

(c) global, more highly conserved

(d) local, low conserved

The question was asked in an online quiz.

My doubt stems from Localized Alignments in Sequences topic in section Multiple Sequence Alignment of Bioinformatics

Answer 1

The correct choice is (c) global, more highly conserved

For explanation I would say: Profiles are found by performing the global MSA of a group of sequences and then removing the more highly conserved regions in the alignment into a smaller MSA. A scoring matrix for the MSA, called a profile, is then made. The profile is composed of columns much like a mini-MSA and may include matches, mismatches, insertions, and deletions.