Question

Which of the following is untrue about Whole Genome Alignment?

(a) This helps to reveal the presence of conserved functional elements

(b) It doesn’t help to understand sequence conservation between genomes

(c) It be accomplished through direct genome comparison or genome alignment

(d) The alignment at the genome level is fundamentally no different from the basic sequence alignment

The question was posed to me during an internship interview.

I'd like to ask this question from Comparative Genomics topic in division Genome Mapping, Assembly and Comparison of Bioinformatics

Answer 1

Right choice is (b) It doesn’t help to understand sequence conservation between genomes

The best explanation: Regular alignment programs tend to be error prone and inefficient when dealing with long stretches of DNA containing hundreds or thousands of genes. Another challenge of genome alignment is effective visualization of alignment results. Because it is obviously difficult to sift through and make sense of the extremely large alignments, a graphical representation is a must for interpretation of the result.