Question

Which of the following is untrue about LAGAN?

(a) It stands for Limited Area Global Alignment of Nucleotides

(b) It is a web-based program designed for pairwise alignment of small fragments of genomes only

(c) It first finds anchors between two genomic sequences using an algorithm that identifies short, exactly matching words

(d) Regions that have high density of words are selected as anchors

I got this question in an online quiz.

This interesting question is from Comparative Genomics in section Genome Mapping, Assembly and Comparison of Bioinformatics

Answer 1

The correct option is (b) It is a web-based program designed for pairwise alignment of small fragments of genomes only

Explanation: It is a web-based program designed for pairwise alignment of large genomes. The unique feature of this program is that it is able to take into account degeneracy of the genetic codes and is therefore able to handle more distantly related genomes.